Impact of Prenatal Stress on Autonomic Nervous System Functioning and Psychopathology Risk in Early Childhood

The Harvey Mom Study

Abstract: Prior human and animal research suggests prenatal stress alters developmental systems that support stress and emotion regulation in offspring, which may underlie vulnerability to psychopathology risk. We examined prospective associations between prenatal stress from a natural disaster and infant biobehavioral outcomes across toddlerhood. Women pregnant during Hurricane Harvey in 2017 completed assessments of their objective levels of hardship and their subjective distress from the disaster. Offspring (n = 47) completed follow-up assessments at 24 months to collect autonomic nervous system activity (respiratory sinus arrhythmia, RSA; heart rate, HR) during a stressor task. Parents assessed their children’s behavioral problems at 24 and 48 months of age. Increased objective hardship was associated with greater HR reactivity and recovery. Prenatal subjective distress was associated with increased child behaviour problems at 24 months. Higher behaviour problems at 24 months of age were also associated with HR reactivity and recovery. No significant effects with RSA reactivity or recovery were observed. Findings suggest that prenatal stress is an important predictor of offspring biobehavioral risk. Further research is needed to explore longitudinal pathways.

Published: May 10, 2026

Citation: Lipschutz, R., S. King, C. Sharp, et al. 2026. “ Impact of Prenatal Stress on Autonomic Nervous System Functioning and Psychopathology Risk in Early Childhood: The Harvey Mom Study.” Infant and Child Development, 35(3). https://doi.org/10.1002/icd.70106